Modafinil increased resting heart rate (9.2☒.0 bpm mean 95% confidence interval, 4.7 to 13.6 P=0.001), resting systolic blood pressure (7.3☓.2 mm Hg 95% CI, 0.2 to 14.4 P=0.044), and resting diastolic blood pressure (5.3☑.7 mm Hg 95% CI, 1.4 to 9.1 mm Hg P<0.012). We compared oral modafinil (400 mg×1) versus placebo in 12 healthy hospitalized normal subjects in a randomized double-blind, placebo-controlled cross-over study for 3 days each with subjects in 150 mEq sodium, 70 mEq potassium balance at the Vanderbilt General Clinical Research Center. We assessed the effect of modafinil on autonomic nervous system. The autonomic effects of modafinil (Provigil), a psychostimulant widely used to attenuate fatigue and promote wakefulness, are currently unexplored. Customer Service and Ordering Information.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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